SAB4502158

Anti-BRP44L antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: MPC1, Mitochondrial pyruvate carrier 1, Brain protein 44-like protein
• Codice UNSPSC: 12352203
• NACRES: NA.41
• Coniugato: unconjugated
• application: ELISA; IF; IHC; WB
• Clone: polyclonal
• Reattività contro le specie: rat, mouse, human
• citations: 10
• tecniche: ELISA: 1:20000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: antigen 12 kDa
• Reattività contro le specie: rat, mouse, human
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:20000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• N° accesso NCBI: Q9Y5U8
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... BR44L(51660)

Descrizione

Descrizione generale

MPC1 (mitochondrial pyruvate carrier 1) gene is mapped to human chromosome 6q27. MPC1 encodes a 12kDa, protein containing five exons and two membrane spanning α helixes. Anti-BRP44L Antibody detects endogenous levels of total BRP44L protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human BRP44L.

Immunogen Range: 11-60

Applicazioni

Anti-BRP44L antibody produced in rabbit has been used to check the effect of mitochondrial TOM70 (translocase of the outer membrane protein 70) on MPC1 (mitochondrial pyruvate carrier 1) expression.

Azioni biochim/fisiol

MPC1 (mitochondrial pyruvate carrier 1) is a key player in pyruvate metabolism. It transports pyruvate into the inner mitochondrial matrix. Lowered MPC1 expression, elevates glycolysis due to a shift in metabolism to fatty acid oxidation. This accounts for the pathogenesis of cancer and other diseases. Downregulation of this gene is observed in colon adenocarcinoma.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable