SAB4500078

Anti-p15 INK antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: CDKN2B, CDN2B, Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 14 kDa
• Reattività contro le specie: mouse, human, rat
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• N° accesso NCBI: P42772
• N° accesso UniProt: P42772
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CDKN2B(1030)

Descrizione

Descrizione generale

Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

Cyclin-dependent kinase inhibitor 2B (CDKN2B) gene codes for tumor-suppressor p15INK4B protein. p15INK4B is a member of the INK4 family of protein kinase inhibitors. In bone marrow cells, p15INK4B expression is mainly seen at a high level in maturing monocytes/macrophages and lymphocytes. It is located in the nucleus and cytoplasm. The CDKN2B gene is mapped to human chromosome 9p21.3. Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human p15 INK.

Immunogen Range: 89-138

Applicazioni

Anti-p15 INK antibody produced in rabbit has been used in western blot (1:500).

Azioni biochim/fisiol

Cyclin-dependent kinase inhibitor 2B (CDKN2B) plays a key role in the cell cycle and senescence. It participates in the differentiation of the hematopoietic cell. CDKN2B gene is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL). Homozygous deletion of the CDKN2B gene or p15INK4B locus on chromosome results in glioblastoma multiforme (GBM). Silencing of p15INK4B is associated with myelodysplastic syndromes, leukemia, and myeloproliferative diseases.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable