SAB4301136
Anti-c-Myc Tag antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
Myc Tag Antibody, Myc Tag Antibody - Anti-c-Myc Tag antibody produced in rabbit, c- Myc epitope Tag
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.43
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
55 kDa
Concentrazione
1 mg/mL
tecniche
western blot: 1:1000-1:5000 (Cell Lysate)
Isotipo
IgG
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Descrizione generale
c-Myc (v-myc avian myelocytomatosis viral oncogene homolog) is a transcription factor, which is coded by MYC gene. It was first described as a homolog of an avian retroviral oncogene. It belongs to the family of transcription factors which are characterized by basic region helix-loop-helix/leucine zipper. Along with N-Myc and L-Myc, it forms the MYC proto-oncogene family. It forms a heterodimer with MAX, and this heterodimer binds to the E-boxes/CACGTG sequence motif on DNA. This gene is localized to human chromosome 8q24.
Specificità
The antibody detects transfected proteins contanining c-Myc Tag.
Immunogeno
Synthetic peptide: C-EQKLISEEDL conjugated with KLH.
Applicazioni
Anti-c-Myc Tag antibody produced in rabbit has been used in western blotting.
Azioni biochim/fisiol
v-myc avian myelocytomatosis viral oncogene homolog belongs to MYC family. When overexpressed, these proteins can delay the resolution of DNA lesions and cause DNA double-strand breaks (DSBs) and genome instability. This transcription factor MYC helps in regulating long noncoding RNAs (lncRNAs), which has been implicated in cancer cell proliferation and tumorigenesis. Its overexpression is also associated with various cancers, and in particular B cell lymphomas. Elevated expression of c-MYC inhibits the ability of B cell lymphomas to functionally present antigens/peptides to CD4+ T cells. It is associated with Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL).
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
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I clienti hanno visto anche
MYC impairs resolution of site-specific DNA double-strand breaks repair.
Ambrosio S, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 774, 6-13 (2015)
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo A N, et al.
British Journal of Cancer, 110(11), 2688-2688 (2014)
Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.
Kim T, et al.
Journal of the National Cancer Institute, 107(4), dju505-dju505 (2015)
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm K M, et al.
American Journal of Surgical Pathology, 39(3), 294-303 (2015)
Sayo Kodama et al.
mBio, 13(5), e0223622-e0223622 (2022-09-27)
Many biotrophic and hemibiotrophic fungal pathogens use appressoria to directly penetrate the host plant surface. In the cucumber anthracnose fungus Colletotrichum orbiculare, differentiation of appressoria requires a proper G1/S cell cycle progression, regulated by the GTPase-activating protein complex CoBub2-CoBfa1 and
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