SAB4200843

Anti-BCOR antibody, Mouse monoclonal

clone BR-4, purified from hybridoma cell culture

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Forma dell’anticorpo: purified from hybridoma cell culture
• Clone: BR-4
• Stato: liquid
• Reattività contro le specie: human
• Concentrazione: ~1 mg/mL
• tecniche: immunoblotting: 2-4 μg/mL using human HeLa nuclear extract; immunofluorescence: 2-4 μg/mL using human HeLa cells
• Isotipo: IgG1
• N° accesso UniProt: Q6W2J9
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified

Descrizione

Descrizione generale

BCOR encodes a ubiquitously expressed protein which is involved in BCL6-mediated transcriptional repression.1 Originally it was identified as a novel BCL6 corepressor via its interaction with the site-specific DNA-binding transcription factor BCL6, whose aberrant expression drives formation of diffuse large B-cell lymphomas.

Specificità

Monoclonal Anti-BCOR antibody specifically recognizes human BCOR protein.

Applicazioni

The antibody may be used in various immunochemical techniques including Immunoblotting (∼190 kDa) and Immunofluorescence.

Azioni biochim/fisiol

NCOR and SMRT, was recently demonstrated to occupy the majority of its DNA binding sites independently from BCL6, reflecting its multiple interaction partners. BCOR also forms a Polycomb repressor complex 1 (PRC1)-like complex with PCGF1, KDM2B, RING1, SKP1, RYBP, and RNF2, and can bind to both class I and II histone deacetylases.1 BCOR is specifically and strongly expressed during embryonic development where it plays a critical role in transcriptional regulation, as BCOR mutations are associated with the X-linked inherited diseases Lenz microphthalmia and Oculofaciocardiodental syndrome (OFCD).

Stato fisico

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Stoccaggio e stabilità

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable