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SAB4200722

Sigma-Aldrich

Anti-Band 3 antibody, Mouse monoclonal

clone BIII-136, purified from hybridoma cell culture

Sinonimo/i:

AE 1, Anion exchange protein 1, Anion exchanger 1, Band 3 anion transport protein, Solute carrier family 4 member 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

mouse

Livello qualitativo

200

Forma dell’anticorpo

purified from hybridoma cell culture

Tipo di anticorpo

primary antibodies

Clone

BIII-136, monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

immunoblotting: 2-4 μg/mL (human erythrocytes ghosts extract)
immunoprecipitation (IP): suitable

Isotipo

IgG2a

N° accesso UniProt

P02730

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SLC4A1(6521)

Descrizione generale

Anti-Band 3 antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the BIII-136 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with glycophorin B purified from human erythrocytes.

Applicazioni

Anti-Band 3 antibody, Mouse monoclonal may be used in immunoblotting and immunoprecipitation.

Azioni biochim/fisiol

As a response to an oxidative stress, Band 3 protein forms clusters and clear damaged and aged RBCs from circulation. Enhanced band 3 protein clustering is implicated in RBC disorders such as hemolytic anemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, malaria and sickle-cell disease.

Stato fisico

Glycophorin B purified from human erythrocytes
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Akihiro Moriyama et al.
Scientific reports, 5, 17427-17427 (2015-12-01)
Membrane proteins interact with membrane lipids for their structural stability and proper function. However, lipid-protein interactions are poorly understood at a molecular level especially in the live cell membrane, due to current limitations in methodology. Here, we report that amphiphilic
Kodjo Ayi et al.
Blood, 104(10), 3364-3371 (2004-07-29)
High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and glucose-6-phosphate dehydrogenase (G6PD) deficiency in regions with high incidence of Plasmodium falciparum malaria and case-control studies support the
Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion.
Giel J C G M Bosman et al.
Blood transfusion = Trasfusione del sangue, 8 Suppl 3, s48-s52 (2010-07-08)
Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion
Bosman G, et al.
Blood Transfusion = Trasfusione del Sangue, 8(Suppl 3), s48-s48 (2010)
J R Pawloski et al.
Nature, 409(6820), 622-626 (2001-02-24)
Previous studies support a model in which the physiological O2 gradient is transduced by haemoglobin into the coordinate release from red blood cells of O2 and nitric oxide (NO)-derived vasoactivity to optimize oxygen delivery in the arterial periphery. But whereas
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