SAB4200471

Anti-SND1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinonimo/i: Anti-TDRD11, Anti-staphylococcal nuclease and tudor domain containing 1, p100
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen ~102 kDa
• Reattività contro le specie: rat, mouse, human
• Concentrazione: ~1.0 mg/mL
• tecniche: immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells; western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.
• N° accesso UniProt: Q7KZF4
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SND1(27044) ; mouse ... Snd1(56463) ; rat ... Snd1(64635)

Descrizione

Descrizione generale

Staphylococcal nuclease and tudor domain containing 1 (SND1) protein contains five staphylococcal nuclease-like domains and a tudor-like domain. SND1 is a component of the RNA-induced silencing complex (RISC). This gene is highly conserved from yeast to human.

Immunogeno

peptide corresponding to the C-terminal region of human SND1 (GeneID: 27044), conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Applicazioni

Anti-SND1 (C-terminal) antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.

Azioni biochim/fisiol

Staphylococcal nuclease and tudor domain containing 1 (SND1) has been shown to be involved in the regulation of transcription and RNA biogenesis. It is known to interact with nucleic acids and proteins. SND1 promotes the breakdown of hyper-edited inosine-containing miRNA precursors. It modulates miRNA transcription and translation through RNA editing by ADAR (adenosine deaminase acting on RNA). Increased SND1 expression is seen in human colon cancer tissues and cell lines.

Stato fisico

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable