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Altri documenti

SAB4200151

Sigma-Aldrich

Anti-Drosha antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinonimo/i:

Anti-ETOHI2, RANSE3L, Anti-RN3, Anti-RNASEN, Anti-RNC, Anti-RNase III, Anti-p241, Anti-ribonuclease type III, nuclear

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 130-160 kDa

Reattività contro le specie

human

Concentrazione

~1.0 mg/mL

tecniche

indirect immunofluorescence: 2.5-5 μg/mL using paraformaldehyde fixed HEK-293T cells.
western blot: 2-4 μg/mL using HeLa nuclear cell lysates.

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RNASEN(29102)

Descrizione generale

Drosha ribonuclease III (Drosha) is encoded by the gene mapped to human chromosome 5p13.3. It is a double-stranded RNA (dsRNA)-specific RNase III enzyme. The encoded protein contains RNase III domains (RIIIDs) on the top and central domain (CED) at the bottom. In addition, it also contains unique non-canonical zinc-finger motifs.

Applicazioni

Anti-Drosha antibody produced in rabbit has been used in western blotting and immunofluorescence.

Azioni biochim/fisiol

Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA).Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA). Mutation in the gene is associated with development of Epithelial ovarian cancer (EOC). Knockdown of Drosha can enhance the sensitivity of gastric cancer to epirubicin.

Stato fisico

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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A novel role for GSK3? as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
Fletcher CE
Nucleic Acids Research (2016)
[Knockdown of Drosha promotes chemosensitivity of epirubicin for gastric cancer MGC-803 cells].
Xu L
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32, 1207-1211 (2016)
Niya L Morris et al.
Biochimica et biophysica acta, 1863(10 Pt B), 2645-2653 (2017-04-14)
Ethanol exposure at the time of burn injury is a major contributor to post-burn pathogenesis. Many of the adverse effects associated with ethanol and burn injury are linked to an impaired intestinal barrier. The combined insult causes intestinal inflammation, resulting
Xiaoxiao Zhang et al.
Biochimica et biophysica acta, 1860(12), 1179-1188 (2017-11-08)
microRNAs (miRNAs) are first transcribed as long, primary transcripts, which are then processed by multiple enzymes and proteins to generate the single-stranded, approximately 22-nucleotide (nt)-long mature miRNAs. A critical step in animal miRNA biogenesis is the cleavage of primary miRNA
Structure of Human DROSHA.
Kwon SC
Cell, 164, 81-90 (2016)
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