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SAB4200147

Sigma-Aldrich

Anti-FHOD1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinonimo/i:

Anti-FH1/FH2 domain-containing protein 1, Anti-FHOS, Anti-Formin homology-2 domain-containing protein 1, Anti-formin homolog overexpressed in spleen 1, Anti-formin homology 2 domain-containing protein 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

~130 kDa

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μL

Concentrazione

~1.0 mg/mL

tecniche

immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human spleen sections and biotin, ExtrAvidin® peroxidase staining system
western blot: 0.5-1.0 μg/mL using whole extracts of human K562 cells

N° accesso UniProt

Q9Y613

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FHOD1(29109)

Descrizione generale

Formin homology domain protein 1 (FHOD1) is an important endothelial formin. It is also called as Fhos1. FHOD1 is located on human chromosome 16q22.

Applicazioni

Anti-FHOD1 antibody has been used in western blotting.

Azioni biochim/fisiol

Formin homology domain protein 1 (FHOD1) participates in actin reorganization in vascular endothelial cells, stimulated by thrombin. It plays an important role in the generation of stress fibres in vascular endothelial cells. FHOD1 is considered as a therapeutic target to modulate endothelial permeability.

Note legali

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Pascale Monzo et al.
Molecular biology of the cell, 27(8), 1246-1261 (2016-02-26)
Glioblastomas are extremely aggressive brain tumors with highly invasive properties. Brain linear tracks such as blood vessel walls constitute their main invasive routes. Here we analyze rat C6 and patient-derived glioma cell motility in vitro using micropatterned linear tracks to
Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.
Monzo P, et al.
Molecular Biology of the Cell, 27(8), 1246-1261 (2016)
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
Takeya R, et al.
The Embo Journal, 27(4), 618-628 (2008)
Next Generation Sequencing in Cancer Research, Volume 2, 2, 317-343 (2015)
Xuemeng Shi et al.
Journal of molecular cell biology, 13(12), 876-888 (2021-11-01)
Both the mechanosensitive actin cytoskeleton and caveolae contribute to active processes such as cell migration, morphogenesis, and vesicular trafficking. Although distinct actin components are well studied, how they contribute to cytoplasmic caveolae, especially in the context of mechano-stress, has remained

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