SAB3501155

Monoclonal Anti-DC-SIGN [8B6] antibody produced in mouse

affinity purified immunoglobulin (IgG)

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity purified immunoglobulin (IgG)
• Tipo di anticorpo: primary antibodies
• Clone: monoclonal
• Forma fisica: liquid
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1, kappa
• N° accesso UniProt: Q9NNX6
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CD209(30835)

Descrizione

Descrizione generale

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Immunogeno

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Applicazioni

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Stato fisico

Supplied in PBS containing 0.02% sodium azide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable