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Key Documents

SAB2701819

Sigma-Aldrich

Anti-PCNA antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

cb16, fb36g03, pcna, wu:fa28e03

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

zebrafish, (Japanese Medaka)

tecniche

immunohistochemistry: suitable
western blot: 500-3000

N° accesso NCBI

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

zebrafish ... pcna(30678)

Descrizione generale

Proliferating cell nuclear antigen (PCNA) is a ring-shaped homotrimer protein, that is located at the center of the faithful duplication of eukaryotic genomes. Since it encircles the DNA, PCNA is also known as a sliding clamp. This gene is mapped to human chromosome 20p12.3.

Immunogeno

Recombinant protein containing a sequence corresponding to a region within amino acids 31 and 222 of pcna according to NP_571479

Applicazioni

Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000, IHC-Wm: 1:50-1:500, Immunostaining: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Anti-PCNA antibody has been used in the detection of proliferating cells by immunofluorescence.

Azioni biochim/fisiol

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase′s processibility during elongation of the leading strand.
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, which are required for the duplication of DNA. It acts as a cell cycle regulatory protein. This protein regulates apoptosis. PCNA is also involved in non-replicative DNA synthesis events.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Aquatic Chronic 3 - Skin Sens. 1

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Forging ahead through darkness: PCNA, still the principal conductor at the replication fork.
Katherine NC and George-Lucian M
Molecular Cell, 65(3), 380?392-380?392 (2017)
Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.
Kei JNC, et al.
Neural Dev., 12(1), 12-12 (2017)
The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies.
Wang X, et al.
Medicine, 96(41), e8254-e8254 (2017)
PCNA (proliferating cell nuclear antigen)
Stoimenov I and Helleday T
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 16(3) (2012)
Jeremy Ng Chi Kei et al.
Neural development, 12(1), 12-12 (2017-07-15)
Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural retina of zebrafish, Müller glia are the main stem cell source

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