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Merck
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SAB2100069

Sigma-Aldrich

Anti-AFF3 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-AF4/FMR2 family, member 3, Anti-LAF4, Anti-MLLT2-like

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

133 kDa

Reattività contro le specie

human

Concentrazione

0.5 mg - 1 mg/mL

tecniche

western blot: suitable

N° accesso UniProt

P51826

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... AFF3(3899)

Descrizione generale

AF4/FMR2 family member 3 (AFF3), a tissue-restricted nuclear transcriptional activator, is mainly expressed in the lymphoid tissue. This RNA binding protein is a member of the AF4/LAF4/FMR2/AF5q31 family. AFF3 is a component of the transcriptional super elongation complex. It is expressed at a high level in the thymus. AFF3 has two domains with transactivation activity. This lymphoid-specific gene, is located on the human chromosome 2q11.2.

Immunogeno

Synthetic peptide directed towards the middle region of human AFF3

Azioni biochim/fisiol

AF4/FMR2 family member 3 (AFF3) participates in transcriptional regulation. It is a potential clinical modulator of estrogen receptor (ER) signaling. This transcription activator can play a role in lymphoid development and cancer. It can bind to double-stranded DNA in vitro. AFF3 overexpression causes tamoxifen resistance and estrogen-independent proliferation in ER+ human breast tumors.

Sequenza

Synthetic peptide located within the following region: APATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD

Stato fisico

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Yawei Shi et al.
Journal of experimental & clinical cancer research : CR, 37(1), 254-254 (2018-10-18)
Although tamoxifen is a highly effective drug for treating estrogen receptor-positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acquired drug resistance. Unfortunately, few molecular mediators of tamoxifen resistance have been
Norine Voisin et al.
American journal of human genetics, 108(5), 857-873 (2021-05-08)
The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants

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