SAB1408000

Anti-GRHL2 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: BOM, DFNA28, FLJ11172, FLJ13782, MGC149294, MGC149295, TFCP2L3
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen ~71.1 kDa
• Reattività contro le specie: human
• tecniche: indirect immunofluorescence: suitable; western blot: 1 μg/mL
• N° accesso NCBI: NM_024915.1
• N° accesso UniProt: Q6ISB3
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... GRHL2(79977)

Descrizione

Descrizione generale

Grainyhead like transcription factor 2 (GRHL2) encodes a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28). Grainyhead like transcription factor 2 (GRHL2) is an epithelial regulatory factor. GRHL2 is homologous to Drosophila grainyhead. GRHL2 gene is located on human chromosome 8q22.3.

Immunogeno

GRHL2 (NP_079191.1, 1 a.a. ~ 625 a.a) full-length human protein.

Sequence
MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKVTLMEI

Applicazioni

Anti-GRHL2 antibody produced in mouse has been used in:

• Immunofluorescence
• Western blotting
• Co-immunoprecipitation
• Immunohistochemistry

Azioni biochim/fisiol

Grainyhead like transcription factor 2 (GRHL2) inhibits epithelial-to-mesenchymal transition, which is necessary for cell migration. It is involved in neural tube closure, epithelial morphogenesis and barrier formation during embryogenesis. It contributes to carcinogenesis. GRHL2 regulates epithelial plasticity of pancreatic ductal adenocarcinoma (PDAC) progression.

Stato fisico

Solution in phosphate buffered saline, pH 7.4

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable