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Documenti fondamentali

SAB1405796

Sigma-Aldrich

Anti-FASN antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Sinonimo/i:

FAS, MGC14367, MGC15706, OA-519, SDR27X1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen ~48.3 kDa

Reattività contro le specie

human

tecniche

indirect immunofluorescence: suitable
western blot: 1 μg/mL

N° accesso NCBI

BC007909.1

N° accesso UniProt

P49327

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FASN(2194)

Descrizione generale

FASN (fatty acid synthase) encodes a fatty acid synthase (FAS) enzyme. This gene is located on human chromosome 17.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-α (ER-α), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-α. (provided by RefSeq)

Immunogeno

FASN (AAH07909.1, 1 a.a. ~ 439 a.a) full-length human protein.

Sequence
MSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG

Azioni biochim/fisiol

FASN (fatty acid synthase) is essential for de novo fatty-acid synthesis. It plays a major role in glioma neovascularization. The product of this gene helps in the production of fatty acids from acetyl-CoA and malonyl-CoA. Absence of FASN may block migration, invasion and healing of hepatoma carcinoma cells by reducing HIF-1α (hypoxia-inducible factor 1-α) and IGFBP1 (insulin-like growth factor binding protein-1).

Stato fisico

Solution in phosphate buffered saline, pH 7.4

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Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
08338

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Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.
Bastos DC, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 97(2), 194-194 (2017)
FASN, dietary fat intake, and risk of uterine leiomyomata in the Black Women's Health Study
Wise LA, et al.
Fertility and Sterility, 106(5), 1136-1141 (2016)
Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1?/IGFBP1 pathway
Gong J, et al.
International Journal of Oncology, 50(3), 883-892 (2017)
Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma
Zhou Y, et al.
Journal of Cancer Research and Clinical Oncology, 142(12), 2447-2459 (2016)
Lakshmi Reddy Bollu et al.
Cell cycle (Georgetown, Tex.), 13(15), 2415-2430 (2014-12-09)
Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as

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