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Key Documents

SAB1300896

Sigma-Aldrich

Anti-LECT2 (N-term) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-HLECT2, Anti-LECT2, Anti-Leukocyte cell-derived chemotaxin 2

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

tecniche

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... LECT2(3950)

Descrizione generale

Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine, encoded by the gene mapped to human chromosome 5q31.1–q32. The gene spanning ~8kb of genomic DNA contains four exons and three introns. LECT2 is a secreted protein with a molecular mass of 16kDa. The encoded protein is mainly expressed in vascular, endothelial and smooth muscle cells, adipocytes, cerebral nerve cells, apical squamous epithelia, parathyroid cells, sweat, sebaceous glandular epithelia and Hassall bodies. Additionally, it is also expressed at high levels in fetal and adult liver.

Immunogeno

LECT2 (NP_002293, 34-68)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LECT2.

Azioni biochim/fisiol

Leukocyte cell-derived chemotaxin 2 (LECT2) acts as a chemotactic factor for neutrophils. It is also implicated in the inflammatory response and insulin resistance. Low serum LECT2 level increases the risk of susceptibility to diabetic retinopathy (DR). Overexpression of the gene has been observed in circulating plasma of non-alcoholic fatty liver disease (NAFLD) patients.

Stato fisico

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.
Yamagoe S
Genomics, 48, 324-329 (1998)
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.
Jeronimo SM
Genes and Immunity, 8(7), 539-551 (2007)
Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis.
Yoo HJ
PLoS ONE, 12 (2017)
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.
Jeronimo SM
Genes and Immunity, 8, 539-551 (2007)
Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.
Yamagoe S
Genomics, 48(3), 324-329 (1998)

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