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S4936

Sigma-Aldrich

Anti-Sodium Channel, Brain Type I (α subunit) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinonimo/i:

Anti-BI, Anti-SP11I, Anti-Scna1

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About This Item

Numero MDL:
MFCD02097410
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

Reattività contro le specie

rat, mouse

tecniche

immunohistochemistry: suitable using rat brain section
western blot: 1:200 using rat brain membranes

N° accesso UniProt

P04774

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... Scn1a(20265)
rat ... Scn1a(81574)

Immunogeno

synthetic peptide corresponding to amino acids 465-481 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP11I) with additional N-terminal lysine and tyrosine, conjugated to KLH. The epitope corresponds to the sequence in the intracellular loop between the I and II domains of type I VGSC α subunit. Homology with human is identical.

Stato fisico

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312,H412

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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D Gordon et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(23), 8682-8686 (1987-12-01)
Anti-peptide antibodies that distinguish between the rat brain sodium channel subtypes referred to as RI and RII were prepared and used to determine their relative expression in nerve and muscle tissues. Sodium channels purified from rat brain are approximately 18%
R E Westenbroek et al.
Neuron, 3(6), 695-704 (1989-12-01)
Immunocytochemical localization of Na+ channel subtypes RI and RII showed that RI immunoreactivity is relatively low and homogeneous along the rostral-caudal extent of sagittal brain sections, whereas RII staining is heterogeneous and relatively dense in the forebrain, substantia nigra, hippocampus
M Noda et al.
Nature, 322(6082), 826-828 (1986-08-03)
The voltage-gated sodium channel is a transmembrane protein essential for the generation of action potentials in excitable cells. It has been reported that sodium channels purified from the electric organ of the electric eel, Electrophorus electricus, and from chick cardiac
R E Westenbroek et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(6), 2259-2267 (1992-06-01)
Type I and type III Na+ channels are localized mainly in neuronal cell bodies in mouse brain. Type II channels are preferentially localized in unmyelinated fiber tracts but are not detectable in normally myelinated fibers. In shiverer mice, which lack

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