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Key Documents

RAB0204

Sigma-Aldrich

Human GDF-15 / MIC-1  ELISA Kit

for serum, plasma, cell culture supernatant and urine

Sinonimo/i:

GDF-15, Growth/differentiation factor 15 , MIC-1, Macrophage inhibitory cytokine 1

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About This Item

Codice UNSPSC:
41116158
NACRES:
NA.32

Reattività contro le specie

human

Confezionamento

kit of 96 wells (12 strips x 8 wells)

tecniche

ELISA: suitable
capture ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 pg/mL
standard curve range: 1.1-800 pg/mL

Metodo di rivelazione

colorimetric

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... GDF15(9518)

Descrizione generale

Human GDF-15 / MIC-1 ELISA (enzyme-linked immunosorbent assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of a target protein in biological samples, such as serum, plasma, cell culture supernatants, urine and/or cell and tissue lysates. Growth differentiation factor-15 (GDF-15) is a cytokine for stress-response. It elevates during an inflammatory response and tissue injury. GDF-15 is also associated with cardiometabolic risk. It is localized in the adipocytes, macrophages, cardiomyocytes and vascular smooth muscle cells.

Immunogeno

Recombinant Human GDF15

Applicazioni

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human GDF-15 / MIC-1ELISA (enzyme-linked immunosorbent assay) kit has been used in the quantification of circulating macrophage inhibitory cytokine-1 (MIC-1) in venous blood samples.

Altre note

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

I componenti del kit sono disponibili anche separatamente

N° Catalogo
Descrizione
SDS
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pittogrammi

Corrosion
GHS05

Avvertenze

Warning

Indicazioni di pericolo

H290

Consigli di prudenza

P234 - P390

Classi di pericolo

Met. Corr. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs.
Bloch SA
Thorax, 70(3), 219-228 (2015)
Hilde Engerud et al.
PloS one, 14(1), e0210585-e0210585 (2019-01-16)
Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability of plasma growth differentiation factor 15 (GDF-15)
Azza Abdel Gawad Tantawy et al.
Blood cells, molecules & diseases, 53(4), 189-193 (2014-07-30)
High expression of growth differentiation factor-15 (GDF-15) contributes to pathological iron overload in thalassemia. Sickle cell syndromes are characterized by increased levels of erythropoiesis, although the primary defect involves the destruction of mature erythrocytes. To determine serum GDF-15 in 35
Sébastien Jeay et al.
Cancer research, 78(21), 6257-6267 (2018-08-24)
Activation of p53 by inhibitors of the p53-MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53-MDM2 interaction HDM201 elicits therapeutic
Insulin resistance, type 1 and type 2 diabetes, and related complications 2015
Ndisang J F, et al.
Journal of Diabetes Research (2015)
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