RAB0161
Phospho-EGFR (pSer1070) ELISA Kit
for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates
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About This Item
Codice UNSPSC:
41116158
NACRES:
NA.32
Prodotti consigliati
Reattività contro le specie
mouse, human, rat
tecniche
ELISA: suitable
capture ELISA: suitable
input
sample type tissue lysate
sample type cell lysate
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... EGFR(1965)
Descrizione generale
The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.
Immunogeno
EGFR (pTyr1070) synthetic phosphopeptide
Applicazioni
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Azioni biochim/fisiol
The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.
Avvertenze
Warning
Indicazioni di pericolo
Classi di pericolo
Met. Corr. 1 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
8A - Combustible corrosive hazardous materials
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations.
Han W and Lo H W
Cancer Letters, 318(2), 124-134 (2012)
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Lanzetti L, et al.
Nature, 408(6810), 374-374 (2000)
Targeting the EGFR signaling pathway in cancer therapy.
Seshacharyulu P, et al.
Expert Opinion on Therapeutic Targets, 16(1), 15-31 (2012)
EGF receptor.
Wells A
The International Journal of Biochemistry & Cell Biology, 31(6), 637-643 (1999)
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
Sanson M, et al.
Human Molecular Genetics, 20(14), 2897-2904 (2011)
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