Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

R8626

Sigma-Aldrich

Rifamycin SV sodium salt

potency: ≥ 900 IU/mg (anhydrous basis)

Sinonimo/i:

2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl- 21-acetate monosodium salt, Rifamycin SV monosodium salt

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C37H46NNaO12
Numero CAS:
14897-39-3
Peso molecolare:
719.75
Numero CE:
238-965-7
Codice UNSPSC:
51283601
ID PubChem:
329824038
NACRES:
NA.76

Forma fisica

powder

Livello qualitativo

200

Potenza

≥ 900 IU/mg (anhydrous basis)

Solubilità

ethanol: soluble 50 mg/mL

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modalità d’azione

protein synthesis | interferes

Stringa SMILE

[Na+].CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)cc([O-])c4c3C2=O

InChI

1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1
YVOFSHPIJOYKSH-NLYBMVFSSA-M

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Categorie correlate

Descrizione generale

Chemical structure: macrolide

Applicazioni

Rifamycin SV is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group. It is used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B.

Azioni biochim/fisiol

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

Confezionamento

1g,5g

Altre note

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Air sensitive. Store under inert gas

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

1-Aminobenzotriazole

Sigma-Aldrich

A3940

1-Aminobenzotriazole

Pentachloronitrobenzene ≥94%

Sigma-Aldrich

P2205

Pentachloronitrobenzene

Rifampicin suitable for plant cell culture, BioReagent, ≥95% (HPLC), powder or crystals

Sigma-Aldrich

R7382

Rifampicin

Pimaricin preparation ~2.5% (γ-irradiated Pimaricin), aqueous suspension

Sigma-Aldrich

P0440

Pimaricin preparation

β-Estradiol 3-(β-D-glucuronide) sodium salt

Sigma-Aldrich

E2127

β-Estradiol 3-(β-D-glucuronide) sodium salt

Rifabutin >98% (HPLC), powder

Sigma-Aldrich

R3530

Rifabutin

Rosuvastatin calcium ≥98% (HPLC)

Sigma-Aldrich

SML1264

Rosuvastatin calcium

I Caruso et al.
Annals of the rheumatic diseases, 41(3), 232-236 (1982-06-01)
Thirty rheumatoid patients with persistent knee effusion were treated intra-articularly with rifamycin SV, 500 mg weekly, or with saline solution, 10 ml, in a double-blind study. A complete disappearance of effusion and an impressive clinical improvement was observed in the
Y Kono et al.
Journal of biochemistry, 91(1), 397-401 (1982-01-01)
The formation of Mn2+- or Cu2+-rifamycin SV complex and the semiquinone radical of rifamycin SV was studied by electron spin resonance spectroscopy. The results indicate that: (1) the complexes Mn2+-rifamycin SV (g parallel = 2.265, g perpendicular = 2.087, A
Zhihui Shao et al.
Archives of microbiology, 193(7), 463-477 (2011-03-23)
Nitrate assimilation has been well studied for Gram-negative bacteria but not so much in the Gram-positive actinomycetes up to date. In a rifamycin SV-producing actinomycete, Amycolatopsis mediterranei strain U32, nitrate not only can be used as a sole nitrogen source
Clinical efficacy of rifamycin SV combined with oxytetracycline in the treatment of caseous lymphadenitis in sheep.
S Senturk et al.
The Veterinary record, 159(7), 216-217 (2006-08-15)
Wei Zhao et al.
Cell research, 20(10), 1096-1108 (2010-06-23)
Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10,236,715 base pairs, is one of the largest
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.