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R3655

Rubitecan

Name: Rubitecan
Brand: SIGMA

powder, ≥98% (HPLC)

Sinonimo/i:

9-nitrocamptothecin

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About This Item

Formula empirica (notazione di Hill):

C₂₀H₁₅N₃O₆

Numero CAS:

91421-42-0

Peso molecolare:

393.35

Numero MDL:

MFCD06656294

Codice UNSPSC:

12352204

ID PubChem:

329824025

NACRES:

NA.77

Prodotti consigliati

Slide 1 of 1

1 of 1

Sigma-Aldrich

5.08321

Dihydroorotate Dehydrogenase Inhibitor, Brequinar

product name

Rubitecan,

Origine biologica

synthetic (organic)

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Punto di fusione

182-186 °C

Solubilità

DMSO: 1 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5c(cccc5nc34)[N+]([O-])=O)C2=O

InChI

1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
VHXNKPBCCMUMSW-FQEVSTJZSA-N

Azioni biochim/fisiol

Topoisomerase I inhibitor. Rubitecan induces protein- linked DNA single strand breaks, blocking DNA and RNA synthesis in dividing cells. This mode of action makes rubitecan a potential chemotherapeutic agent, and it has been used with some success against refractory pancreatic cancer.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Preparation and characterization of novel polymeric micelles for 9-nitro-20(S)-camptothecin delivery.

Jieming Gao et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 34(2-3), 85-93 (2008-04-18)

9-Nitro-20(S)-camptothecin (9-NC) has achieved remarkable curative effect in anticancer research. However, the clinical application of 9-NC is largely hampered by its poor solubility and stability. In this paper, novel amphiphilic block copolymers derived from d,l-lactide, trimethylene carbonate, and methylated poly(ethylene

Biodistribution in mice and severity of damage in rat lungs following pulmonary delivery of 9-nitrocamptothecin liposomes.

Li-Jun Zhang et al.

Pulmonary pharmacology & therapeutics, 21(1), 239-246 (2007-06-15)

This study was designed to investigate in vitro release, in vivo tissue distribution and the damage to the lungs of 9-nitrocamptothecin (9-NC) liposomes. In vitro release of 9-NC from liposomes was carried out in phosphate buffer saline solution (PBS) pH

Self-microemulsifying drug delivery system (SMEDDS) improves anticancer effect of oral 9-nitrocamptothecin on human cancer xenografts in nude mice.

Juan-Li Lu et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(3), 899-907 (2008-04-25)

9-Nitrocamptothecin (9-NC) is an orally administered topoisomerase-I inhibitor for the treatment of pancreatic carcinoma, but its oral absorption and bioavailability are poor. The main objective of this study was to develop optimal 9-nitrocamptothecin (9-NC) microemulsion prepared by self-microemulsifying drug delivery

Anticancer activity of new haloalkyl camptothecin esters against human cancer cell lines and human tumor xenografts grown in nude mice.

Zhisong Cao et al.

Anti-cancer agents in medicinal chemistry, 12(7), 818-828 (2012-05-16)

All chemotherapeutic agents currently in use have a narrow window of therapeutic index of 1 to 1.2. Camptothecin ester compounds are reported to have a wider therapeutic index when being used to treat human xenografts in nude mice. As a

Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients.

Katayoun Derakhshandeh et al.

International journal of nanomedicine, 5, 463-471 (2010-10-20)

The purpose in this study was to investigate poly(ethylene glycol)-modified poly (d,l-lactide-co-glycolide) nanoparticles (PLGA-PEG-NPs) loading 9-nitrocamptothecin (9-NC) as a potent anticancer drug. 9-NC is an analog of the natural plant alkaloid camptothecin that has shown high antitumor activity and is

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