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P7412

Sigma-Aldrich

Pirenzepine dihydrochloride

≥98% (TLC), powder

Sinonimo/i:

5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride

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About This Item

Formula empirica (notazione di Hill):
C19H21N5O2 · 2HCl
Numero CAS:
29868-97-1
Peso molecolare:
424.32
Numero CE:
249-907-5
Numero MDL:
MFCD00055214
Codice UNSPSC:
12352200
ID PubChem:
24277863
NACRES:
NA.77

Saggio

≥98% (TLC)

Forma fisica

powder

Colore

white

Solubilità

H2O: 50 mg/mL

Stringa SMILE

Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24

InChI

1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
FFNMBRCFFADNAO-UHFFFAOYSA-N

Informazioni sul gene

human ... CHRM1(1128)

Descrizione generale

Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.

Applicazioni

Pirenzepine dihydrochloride has been used
  • in transactivation of fibroblast growth factor receptor (FGFR).
  • as a supplement in cell culture.
  • for the stimulation of human fibroblasts

Azioni biochim/fisiol

Selective M1 muscarinic acetylcholine receptor antagonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Hygroscopic; store desiccated at room temperature.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

S1875

(−)-Scopolamine hydrobromide trihydrate

Carbachol An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.

Millipore

212385-M

Carbachol

Carbachol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1511

Carbachol

Atropine sulfate salt monohydrate ≥97% (TLC), crystalline

Sigma-Aldrich

A0257

Atropine sulfate salt monohydrate

Carbamoylcholine chloride ≥98% (titration), crystalline

Sigma-Aldrich

C4382

Carbamoylcholine chloride

V B Aramakis et al.
Synapse (New York, N.Y.), 32(4), 262-275 (1999-05-20)
Previously, we reported that activation of muscarinic receptors modulates N-methyl-D-aspartate (NMDA) receptor-mediated synaptic transmission in auditory neocortex [Aramakis et al. (1997a) Exp Brain Res 113:484-496]. Here, we describe the muscarinic subtypes responsible for these modulatory effects, and a role for
Pirenzepine Dihydrochloride
El-Obeild HA, et al.
Anal. Profiles Drug Subst., 16, 445-506 (1987)
Pirenzepine
Carmine AA and Brogden RN
Drugs, 30(2), 85-126 (1985)
Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult sensory neurons
Sabbir MG, et al.
Frontiers in Neuroscience, 12(3), 229-237 (2018)
A Elhusseiny et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19(7), 794-802 (1999-07-21)
Acetylcholine is an important regulator of local cerebral blood flow. There is, however, limited information available on the possible sites of action of this neurotransmitter on brain intraparenchymal microvessels. In this study, a combination of molecular and functional approaches was
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