P5396

Phosphomycin disodium salt

antibacterial MurA inhibitor

• Sinonimo/i: (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
• Formula empirica (notazione di Hill): C₃H₅Na₂O₄P
• Peso molecolare: 182.02
• Beilstein: 4604425
• Numero CE: 247-409-2
• Numero MDL: MFCD22741288
• Codice UNSPSC: 51102829
• ID PubChem: 24278640
• NACRES: NA.85

Proprietà

• Livello qualitativo: 200
• Stato: powder
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: cell wall synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
• InChI: 1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1; QZIQJIKUVJMTDG-JSTPYPERSA-L

Descrizione

Applicazioni

Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.

Azioni biochim/fisiol

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

Altre note

1g,5g,50g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)