P0749
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-HERG, Anti-KCNH2
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
lyophilized powder
Reattività contro le specie
human
tecniche
flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 106 cells)
immunocytochemistry: 1:25
western blot: 1:200 using HEK-KV11.1 transfected cells
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... KCNH2(3757)
mouse ... Kcnh2(16511)
rat ... Kcnh2(117018)
Descrizione generale
The K+ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K+ channels based on the number of transmembrane domains. The voltage-gated Potassium or Kv channels belong to the 6 TM K+ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. Kv11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in Kv11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. Kv11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel Kv11.1 extracellular antibodies are specific to Kv11.1.
Immunogeno
peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.
Applicazioni
Anti-Potassium channel Kv11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of Kv11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.
Stato fisico
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Matteo Conti
Journal of experimental therapeutics & oncology, 4(2), 161-166 (2004-10-27)
A number of experimental evidences in cellular biology and pharmacology demonstrate that K+ channels are involved in the regulatory mechanisms of neoplastic cell proliferation and survival. Among the various types of K+ channels known so far, those that express an
Jingyun Dong et al.
Heliyon, 4(12), e01015-e01015 (2018-12-26)
Molecular testing of the deceased (Molecular Autopsy) is an overlooked area in the United States healthcare system and is not covered by medical insurance, leading to ineffective care for surviving families of thousands of sudden unexpected natural deaths each year.
Cell Surface Expression of Human Ether-a-go-go-Related Gene (hERG) Channels is Regulated by Caveolin-3 via the Ubiquitin Ligase Nedd4-2
Guo, J.
The Journal of Biological Chemistry, (287(40), 33132-33141 (2012)
J S Mitcheson et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(22), 12329-12333 (2000-09-27)
Mutations in the HERG K(+) channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran, M. E. , Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D.
J I Vandenberg et al.
Trends in pharmacological sciences, 22(5), 240-246 (2001-05-08)
The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes. HERG encodes the pore-forming subunit of the rapid component of the delayed
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