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Key Documents

Altri documenti

P0046

Sigma-Aldrich

Pyocyanin

from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine

Sinonimo/i:

5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

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About This Item

Formula empirica (notazione di Hill):
C13H10N2O
Numero CAS:
85-66-5
Peso molecolare:
210.23
Numero MDL:
MFCD01794662
Codice UNSPSC:
12352200
ID PubChem:
329819996
NACRES:
NA.77

product name

Pyocyanin, from Pseudomonas aeruginosa, ≥98% (HPLC)

Origine biologica

Pseudomonas aeruginosa

Livello qualitativo

200

Saggio

≥98% (HPLC)

Forma fisica

solid

Solubilità

DMSO: soluble
acetone: soluble
chloroform: soluble
ethanol: soluble

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

CN1c2ccccc2N=C3C(=O)C=CC=C13

InChI

1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
YNCMLFHHXWETLD-UHFFFAOYSA-N

Applicazioni

Pyocyanin has been used as a biomarker to detect Pseudomonas aeruginosa.

Azioni biochim/fisiol

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

Nota sulla preparazione

For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections
Alatraktchi F, et al.
Nanomedicine (London, England), 11(16), 2185-2195 (2016)
Pseudomonas aeruginosa Can Be Detected in a Polymicrobial Competition Model Using Impedance
Ward AC, et al.
PLoS ONE, 9(3), e91732-e91732 (2014)
Sheila Pourali Dogaheh et al.
Veterinary immunology and immunopathology, 237, 110265-110265 (2021-05-15)
Severe equine asthma is characterized by airway hyperresponsiveness, neutrophilic inflammation and structural alterations of the lower airways. In asthmatic horses with neutrophilic inflammation, there is insensitivity to corticosteroids characterized by the persistence of neutrophils within the airways with therapy. We
Theerthankar Das et al.
Frontiers in microbiology, 8, 2429-2429 (2018-01-10)
Pyocyanin secreted by
Mariola Andrejko et al.
Acta biochimica Polonica, 66(1), 91-100 (2019-03-05)
Thermally induced unfolding and renaturation capability of alkaline proteases (AprA) of three Pseudomonas aeruginosa strains, i.e. ATCC 27853 and two clinical isolates, was examined. Sequence analyses demonstrated a high level of aprA genes identity (99.24-99.8%) in these bacterial strains. The
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