M7695

Anti-Munc-18-3

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-MUNC18C, Anti-PSP, Anti-Syntaxin Binding Protein 3 (STXBP3), Anti-UNC-18C
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: antigen ~66 kDa
• Reattività contro le specie: rat, mouse, human
• tecniche: western blot: 0.75-1.5 μg/mL using mouse brain extract (S1 fraction)
• N° accesso UniProt: O00186
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... STXBP3(6814) ; mouse ... Stxbp3a(20912) ; rat ... Stxbp3(114095)

Descrizione

Descrizione generale

Mammalian uncoordinated-18-3 (Munc-18-3) (also known as Munc-18c, syntaxin-binding protein 3, STXBP3) is ubiquitously expressed.

Immunogeno

synthetic peptide corresponding to amino acids 578-592 located at the C-terminus of mouse Munc-18-3, conjugated to KLH. This sequence is highly conserved (~90% identity) in human and rat Munc-18-3.

Applicazioni

Anti-Munc-18-3 antibody produced in rabbit has been used in immunohistochemistry and western blotting

Azioni biochim/fisiol

Mammalian uncoordinated-18-3 (Munc-18-3) expressed in 3T3-L1 adipocytes has been shown to interact with syntaxin 2 and 4 and to inhibit the binding of syntaxin-4 to vesicle associated membrane protein 2 (VAMP2). Munc-18c has been suggested to play a role in the docking/fusion of glucose transporter type 4 (GLUT4)-containing vesicles with the cell membrane of 3T3-L1 adipocytes. Heterozygous knock-out of the Munc-18c gene in mice impairs insulin-stimulated GLUT4 translocation in skeletal muscle and increases the susceptibility for severe glucose intolerance.

Munc-18-3 has a role in glucose metabolism and is involved in controlling the translocation of glucose transporter type 4 (GLUT4) in adipocytes.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable