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Merck
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Documenti fondamentali

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M5693

Sigma-Aldrich

MEDICA 16

powder, ≥97% (HPLC)

Sinonimo/i:

3,3,14,14-Tetramethylhexadecanedioic acid

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About This Item

Formula empirica (notazione di Hill):
C20H38O4
Numero CAS:
87272-20-6
Peso molecolare:
342.51
Numero MDL:
MFCD00797684
Codice UNSPSC:
12352200
ID PubChem:
24724539
NACRES:
NA.77

Saggio

≥97% (HPLC)

Forma fisica

powder

Colore

white to beige

Punto di fusione

154-159 °C

Solubilità

DMSO: 10 mg/mL, clear

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O

InChI

1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
HYSMCRNFENOHJH-UHFFFAOYSA-N

Azioni biochim/fisiol

MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Bella Kalderon et al.
American journal of physiology. Endocrinology and metabolism, 284(4), E795-E803 (2002-12-19)
The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The
O Hermesh et al.
Biochimica et biophysica acta, 1457(3), 166-174 (2000-04-25)
Calcium-dependent uncoupling of liver mitochondrial oxidative phosphorylation by a non-metabolizable long chain fatty acyl analogue was compared with uncoupling induced by in vivo thyroid hormone treatment. beta,beta'-Methyl-substituted hexadecane alpha, omega-dioic acid (Medica 16) is reported here to induce a saturable
G Rose-Kahn et al.
Biochimica et biophysica acta, 1042(2), 259-264 (1990-02-06)
Rat liver acetyl-CoA carboxylase activity was inhibited by the free as well as the CoA monothioester of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) (Bar-Tana, J., Rose-Kahn, G. and Srebnik, M. (1985) J. Biol. Chem. 260, 8404-8410 (1985). (1) The CoA
R Hertz et al.
Biochemical pharmacology, 61(9), 1057-1062 (2001-04-13)
Hepatocyte nuclear factor-4alpha (HNF-4alpha) modulates the expression of liver-specific genes that control the production (e.g. apolipoprotein [apo] A-I and apo B) and clearance (e.g. apo C-III) of plasma lipoproteins. We reported that the CoA thioesters of amphipathic carboxylic hypolipidemic drugs
R G Elkin et al.
British poultry science, 33(3), 677-681 (1992-07-01)
1. beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soya-bean meal diets containing 0, 1.5, or
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