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M4949

Sigma-Aldrich

2′-C-Methylcytidine

≥95% (HPLC), powder

Sinonimo/i:

2′-C-Methyl Cytidine, NM107

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About This Item

Formula empirica (notazione di Hill):
C10H15N3O5
Numero CAS:
20724-73-6
Peso molecolare:
257.24
Numero MDL:
MFCD02682947
Codice UNSPSC:
12352200
ID PubChem:
329817997
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥95% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white to off-white

Solubilità

H2O: >20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(N)=NC2=O

InChI

1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1
PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Azioni biochim/fisiol

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
066M4740V
094M4712V
021M4712V

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Sigma-Aldrich

855057

Betulinic acid

Colina idrossido 46 wt. % in H2O

Sigma-Aldrich

292257

Colina idrossido

Z-VAD-FMK solid

Sigma-Aldrich

V116

Z-VAD-FMK

Y-27632 ≥98% (HPLC)

Sigma-Aldrich

Y0503

Y-27632

Natalie E Netzler et al.
Antiviral research, 146, 65-75 (2017-08-02)
Viruses of the Caliciviridae cause significant and sometimes lethal diseases, however despite substantial research efforts, specific antivirals are lacking. Broad-spectrum antivirals could combat multiple viral pathogens, offering a rapid solution when no therapies exist. The RNA-dependent RNA polymerase (RdRp) is
Natalie E Netzler et al.
Antimicrobial agents and chemotherapy, 63(6) (2019-03-20)
Globally, hepatitis E virus (HEV) causes significant morbidity and mortality each year. Despite this burden, there are no specific antivirals available to treat HEV patients, and the only licensed vaccine is not available outside China. Ribavirin and alpha interferon are
Abhilasha Madhvi et al.
Scientific reports, 7(1), 5816-5816 (2017-07-21)
Hepatitis C virus (HCV) is a global pathogen and infects more than 185 million individuals worldwide. Although recent development of direct acting antivirals (DAA) has shown promise in HCV therapy, there is an urgent need for the development of more
Myungeun Lee et al.
Scientific reports, 7, 44676-44676 (2017-03-24)
Despite recent advances in curing chronic hepatitis C (CHC), the high economic burden to therapy, viral drug resistance, difficult to treat hepatitis C virus (HCV) genotypes and patient groups are still of concern. To address this unmet medical needs, we
Navaneethan Palanisamy et al.
Pathogens and global health, 112(4), 210-226 (2018-05-11)
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis

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