L1167

Latanoprost

≥98% (HPLC)

• Sinonimo/i: Isopropil (5Z,9α,11α,15R)-9,11,15-triidrossi-17-fenil-18,19,20-trinor-prost-5-en-1-oato, Isopropil (Z)-7-[(1R,2R,3R,5S)-3,5-diidrossi-2-[(3R)-3-idrossi-5-fenil-pentil]ciclopentil]ept-5-enoato, Xalatan
• Formula empirica (notazione di Hill): C₂₆H₄₀O₅
• Numero CAS: 130209-82-4
• Peso molecolare: 432.59
• Numero MDL: MFCD00216074
• Codice UNSPSC: 12352200
• ID PubChem: 24724523
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: oil
• Colore: colorless to yellow
• Solubilità: DMSO: freely soluble; methanol: soluble
• Ideatore: Johnson & Johnson
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc2ccccc2
• InChI: 1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1; GGXICVAJURFBLW-CEYXHVGTSA-N
• Informazioni sul gene: human ... PTGFR(5737)

Descrizione

Applicazioni

Latanoprost has been used:

• in the preparation of thermo-sensitive hydrogel consisting of curcumin-loaded nanoparticles (CUR-NPs) to determine its therapeutic effects on human trabecular meshwork (TM) cells under oxidative stress.
• as an ester pro-drug to study its effects on the murine ocular surface in mice.
• in the preparation of thermo-sensitive hydrogel to study its effects on controlling ocular hypertension.

Azioni biochim/fisiol

Latanoprost is a potent, selective prostaglandin F2α analog receptor agonist. It is hydrolyzed by esterases into its biologically active form latanoprost acid in the cornea. Latanoprostplays a role in reducing the intraocular pressure (IOP) due to which it has therapeutic effects in treating glaucoma.

Caratteristiche e vantaggi

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H361d
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 2
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type N95 (US)