I9031

Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse

~1 mg/mL, clone 186-2G9, purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: Anti-ICAM-3
• Numero MDL: MFCD01094485
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 186-2G9, monoclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 120 kDa
• Reattività contro le specie: human
• Concentrazione: ~1 mg/mL
• tecniche: direct immunofluorescence: 2 μg using 1 mg protein lysate; flow cytometry: 2 μg using 1 mg protein lysate; immunohistochemistry: 2-4 μg/mL using human tonsil tissue sections; immunoprecipitation (IP): 2 μg using 1 mg protein lysate; western blot: 1-5 μg/mL
• N° accesso UniProt: P32942
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ICAM3(3385)

Descrizione

Descrizione generale

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.

Immunogeno

stimulated human leukocytes.

Azioni biochim/fisiol

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.

Stato fisico

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable