I4011

Insulina

Hybri-Max^™, powder, suitable for hybridoma

• Formula empirica (notazione di Hill): C₂₅₄H₃₇₇N₆₅O₇₅S₆
• Numero CAS: 11070-73-8
• Peso molecolare: 5733.49
• Numero CE: 234-291-2
• Numero MDL: MFCD00131380
• Codice UNSPSC: 12352209
• NACRES: NA.77

Proprietà

• Origine biologica: bovine
• Livello qualitativo: 200
• Grado: Hybri-Max^™
• Stato: powder
• Potenza: ≥20 USP units per mg (dry basis)
• tecniche: cell culture | hybridoma: suitable
• Impurezze: endotoxin, tested
• Solubilità: acidified water, pH 2.0: 2 mg/mL
• Cationi in tracce: Zn: ≤1.0% (dry basis)
• N° accesso UniProt: P01317
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: IXIBAKNTJSCKJM-BUBXBXGNSA-N
• Informazioni sul gene: bovine ... INS(280829) ; cow ... INS(280829)

Descrizione

Descrizione generale

The insulin gene is mapped to human chromosome 11p15.5.

Applicazioni

Insulin from bovine pancreas has been used in endometrium cell culture. It has also been used to perform insulin tolerance test and to study the effect of protein undernutrition in laying hens.

Insulin from bovine pancreas was used during experimental design and treatments. Experimental animals (like cow) were infused with bovine insulin to decrease blood glucose to a constant level.

Azioni biochim/fisiol

Ormone polipeptidico a doppia catena prodotto dalle cellule β delle isole pancreatiche. Il suo peso molecolare è di circa 5800 Da. Le catene α e β sono unite da due ponti disolfuro interconnessi. La catena α contiene un ponte disolfuro interno. L′insulina regola la captazione cellulare, l′utilizzo e lo stoccaggio di glucosio, aminoacidi e acidi grassi e inibisce la rottura di glicogeno, proteine e grassi.

Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. The biological effects of insulin are mediated by insulin receptor (glycoprotein) and it integrates major signaling pathways.

Altre note

InChI: 1S/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-167(94-139-52-60-145(324)61-53-139)226(365)282-153(68-75-186(258)328)217(356)289-160(86-121(4)5)221(360)284-157(73-80-198(342)343)219(358)301-173(100-189(261)331)233(372)297-169(96-141-56-64-147(326)65-57-141)229(368)308-182(241(380)303-175(253(393)394)102-191(263)333)115-398-396-113-180(212(351)270-106-193(335)277-152(71-78-196(338)339)215(354)280-150(50-41-83-268-254(264)265)210(349)269-107-194(336)278-165(92-137-45-35-31-36-46-137)225(364)296-166(93-138-47-37-32-38-48-138)228(367)298-170(97-142-58-66-148(327)67-59-142)236(375)318-206(135(28)323)251(390)319-84-42-51-185(319)244(383)285-151(49-39-40-82-255)213(352)276-134(27)252(391)392)310-248(387)202(128(18)19)315-234(373)163(89-124(10)11)291-227(366)168(95-140-54-62-146(325)63-55-140)295-222(361)159(85-120(2)3)288-207(346)132(25)274-214(353)156(72-79-197(340)341)286-245(384)201(127(16)17)314-235(374)164(90-125(12)13)292-231(370)172(99-144-105-267-119-273-144)300-237(376)176(109-320)279-195(337)108-271-211(350)179(112-395-397-114-181(309-243(183)382)240(379)275-133(26)208(347)304-178(111-322)239(378)316-203(129(20)21)249(388)311-184)306-224(363)162(88-123(8)9)290-230(369)171(98-143-104-266-118-272-143)299-218(357)154(69-76-187(259)329)283-232(371)174(101-190(262)332)302-247(386)200(126(14)15)313-209(348)149(257)91-136-43-33-30-34-44-136/h30-38,43-48,52-67,104-105,118-135,149-185,200-206,320-327H,29,39-42,49-51,68-103,106-117,255-257H2,1-28H3,(H2,258,328)(H2,259,329)(H2,260,330)(H2,261,331)(H2,262,332)(H2,263,333)(H,266,272)(H,267,273)(H,269,349)(H,270,351)(H,271,350)(H,274,353)(H,275,379)(H,276,352)(H,277,335)(H,278,336)(H,279,337)(H,280,354)(H,281,355)(H,282,365)(H,283,371)(H,284,360)(H,285,383)(H,286,384)(H,287,385)(H,288,346)(H,289,356)(H,290,369)(H,291,366)(H,292,370)(H,293,377)(H,294,362)(H,295,361)(H,296,364)(H,297,372)(H,298,367)(H,299,357)(H,300,376)(H,301,358)(H,302,386)(H,303,380)(H,304,347)(H,305,381)(H,306,363)(H,307,359)(H,308,368)(H,309,382)(H,310,387)(H,311,388)(H,312,334)(H,313,348)(H,314,374)(H,315,373)(H,316,378)(H,317,389)(H,318,375)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,391,392)(H,393,394)(H4,264,265,268)/t131-,132-,133-,134-,135+,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,200-,201-,202-,203-,204-,205-,206-/m0/s1

Note legali

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)