HPA013796

Anti-P2RY12 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinonimo/i: P2RY12 Antibody - Anti-P2RY12 antibody produced in rabbit, P2Ry12 Antibody, Anti-ADP-glucose receptor, Anti-ADPG-R, Anti-P2T(AC), Anti-P2Y purinoceptor 12, Anti-P2Y(AC), Anti-P2Y(ADP), Anti-P2Y(cyc), Anti-P2Y12, Anti-P2Y12 platelet ADP receptor, Anti-SP1999
• Codice UNSPSC: 12352203
• Numero Human Protein Atlas: HPA013796
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Nome Commerciale: Prestige Antibodies^® Powered by Atlas Antibodies
• Forma fisica: buffered aqueous glycerol solution
• Reattività contro le specie: human
• Convalida avanzata: orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• tecniche: immunohistochemistry: 1:20-1:50
• Sequenza immunogenica: LTNRQPRDKNVKKCSFLKSEFGLVWHEIV
• N° accesso UniProt: Q9H244
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... P2RY12(64805)

Descrizione

Descrizione generale

Purinergic receptor (P2Y12) is expressed in platelets. P2Y12 is mapped to human chromosome 3q25.1. It belongs to the P2Y receptors family and is predominantly expressed in astrocytes. P2Y12 is predicted to have three ATP binding regions. It has seven transmembrane regions.

Immunogeno

P2Y purinoceptor 12 recombinant protein epitope signature tag (PrEST)

Applicazioni

Anti-P2RY12 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level.

Azioni biochim/fisiol

The gene P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) encodes a G-protein coupled receptor for ADP and ATP coupled to G-proteins that are involved in the negative regulation of adenylyl cyclase second messenger system. It functions in normal platelet aggregation and blood coagulation. Defects in this gene may cause bleeding disorder, platelet type 8 (BDPLT8). It serves as a potential target for the treatment of thromboembolisms and other clotting disorders.

Caratteristiche e vantaggi

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST72772

Stato fisico

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Note legali

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)