H0417

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

• Sinonimo/i: HCF2, HCII, SERPIND1
• Numero CAS: 81604-65-1
• Numero MDL: MFCD00285907
• Codice UNSPSC: 12352202
• NACRES: NA.61

Proprietà

• Origine biologica: human plasma
• Livello qualitativo: 200
• Saggio: ≥90% (SDS-PAGE)
• Forma fisica: aqueous glycerol solution
• PM: ~66 kDa; ~66 kDa
• N° accesso NCBI: NP_000176
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... SERPIND1(3053)

Descrizione

Azioni biochim/fisiol

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

Definizione di unità

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

Stato fisico

50% aqueous glycerol solution (vol/vol)

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable