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GW22778

Sigma-Aldrich

Anti-GSK3a antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rat, mouse, human

Produttore/marchio commerciale

Genway 15-288-22778

tecniche

indirect ELISA: suitable
western blot: suitable

N° accesso NCBI

NP_063937.1

N° accesso UniProt

P49840

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GSK3A(2931)

Immunogeno

Immunogen Sequence: GI # 11995474, sequence 89-100
Synthetic peptide sequence of glycogen synthase kinase 3α.

Applicazioni

Anti-GSK3α antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Glycogen synthase kinase-3α is an enzyme encoded by the GSK3A gene in humans and is located on chromosome 19q13.2. It is a serine-threonine kinase that exists as two isoforms, α and β. GSK-3α is widely expressed throughout the follicles and plays a role in cancer development such as acute myeloid leukemia (AML). It is an important component of the therapeutic actions of drugs used to treat mood disorders and can be a potential target for developing new therapeutic interventions.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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P C Shaw et al.
Genome, 41(5), 720-727 (1998-11-11)
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that exists as two isoforms, alpha and beta, encoded by separate genes. Phosphorylation targets include a variety of cytoplasmic and nuclear proteins. Recent studies found that neurofilaments, amyloid precursor protein, and tau
Xiaohua Li et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(11), 2143-2154 (2010-07-30)
Little is known regarding the mechanisms underlying the complex etiology of mood disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 discovery that lithium inhibits glycogen synthase kinase-3 (GSK3) raised the possibility that impaired inhibition of GSK3
Versha Banerji et al.
The Journal of clinical investigation, 122(3), 935-947 (2012-02-14)
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification and validation of new AML targets. Integration of genomic approaches
Koichi Yamauchi et al.
Archives of dermatological research, 302(4), 263-270 (2009-08-26)
Beta-catenin is involved in the hair follicle morphogenesis and stem cell differentiation, and inhibition of glycogen synthase kinase-3 (GSK-3) increases beta-catenin concentration in the cytoplasm. To examine the effects of GSK-3 inhibition on the hair follicle epithelium, we first examined

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