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GW21469

Anti-PTPRF antibody produced in chicken

Name: Anti-PTPRF antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Receptor-type tyrosine-protein phosphatase F

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About This Item

Codice UNSPSC:

12352203

NACRES:

NA.41

Origine biologica

chicken

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rat, human, mouse

Produttore/marchio commerciale

Genway 15-288-21469

tecniche

western blot: suitable

N° accesso NCBI

NP_002831.1

N° accesso UniProt

P10586

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PTPRF(5792)

Immunogeno

Immunogen Sequence: GI # 4506311, sequence 1151-1225

Recombinant protein tyrosine phosphatase, receptor type, F isoform 1

Applicazioni

Anti-PTPRF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Receptor-type tyrosine-protein phosphatase F is an enzyme encoded by the PTPRF gene in humans. It localizes to adherens junctions and may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling and the canonical Wnt pathway. PTPRF induction occurs by cell-cell contact during cell proliferation that activates ERK-dependent proliferation signaling to prevent cell hyperproliferation and tumor initiation. It acts as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin. PTPRF regulates cell proliferation, response to growth factors and cellular adhesion. Mutation in the gene is associated with breast cancer.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Homozygous truncating PTPRF mutation causes athelia.

Guntram Borck et al.

Human genetics, 133(8), 1041-1047 (2014-05-02)

Athelia is a very rare entity that is defined by the absence of the nipple-areola complex. It can affect either sex and is mostly part of syndromes including other congenital or ectodermal anomalies, such as limb-mammary syndrome, scalp-ear-nipple syndrome, or

Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.

Rabindranath Bera et al.

Hepatology (Baltimore, Md.), 59(6), 2238-2250 (2014-01-29)

It is unclear how proliferating cells elicit suppression on cell proliferation and how cancer cells evade this growth suppression. Using a loss-of-function screening of the human kinome and phosphatome to identify genes suppressing tumor initiation in human hepatocellular carcinoma (HCC)

Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.

T Yang et al.

Molecular carcinogenesis, 25(2), 139-149 (1999-06-12)

The findings that protein tyrosine phosphatases (PTPs) regulate cell proliferation, response to growth factors, and cellular adhesion and the discovery that mutations in PTP genes are associated with breast cancer suggest that altered expression of PTPs contributes to the breast

Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.

Ann Mander et al.

FEBS letters, 579(14), 3024-3028 (2005-05-18)

To test the role of the leukocyte common antigen-related protein tyrosine phosphatase (LAR) as a regulator of insulin receptor (IR) signalling, an siRNA probe against LAR was developed. Knock-down of LAR induced post-receptor insulin resistance with the insulin-induced activation of

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