GW20025F

Anti-GM-CSF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-CSF, Anti-Colony-stimulating factor, Anti-Granulocyte-Macrophage Colony Stimulating Factor, Anti-MGC131935
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: chicken
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: rat, human, mouse
• Produttore/marchio commerciale: Genway 15-288-20025F
• tecniche: indirect ELISA: suitable; western blot: suitable
• N° accesso NCBI: NP_000749.2
• N° accesso UniProt: P04141
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CSF2(1437)

Descrizione

Descrizione generale

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also termed as CSF-2. It is a glycoprotein that consists of 127 amino acids. This gene is located on human chromosome 5q31.

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF-2, is encoded by the gene mapped to human chromosome 5q31-33. The encoded protein is expressed in a wide variety of immune cell types, including macrophages, mast cells and T cells, mainly in response to immune activation and inflammatory cytokines. In addition, it is also secreted in various non-immune cell types, such as endothelial cells, keratinocytes and fibroblasts, following the appropriate stimuli.

Immunogeno

Immunogen Sequence: GI # 27437030, sequence 1-144

Recombinant colony stimulating factor 2

Applicazioni

Anti-GM-CSF antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

Azioni biochim/fisiol

GM-CSF (Granulocyte-macrophage colony-stimulating factor) is a pleiotropic cytokine that regulates the growth and differentiation of granulocytes, macrophages, eosinophils and erythrocytes. The gene is present in a cluster along with interleukin-3 (IL-3), IL-4 and IL-5 on chromosome 5.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates binding of eosinophils to vascular cell adhesion molecule-1 and eosinophil migration into tissues. In addition, it is also implicated in maturation of antigen presenting cells. GM-CSF plays an essential role in modulation of surfactant homeostasis and alveolar macrophage innate immune responses in the lung. It also plays a vital role immune-independent tumor progression. Mutation in the gene is associated with the development of atopic asthma.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used in the treatment of neutropenia and leukemia in combination with chemotherapies. It plays a major role in proliferation and differentiation of granulocytes and macrophages from bone marrow progenitor cells. GM-CSF also play a vital role in immune regulation and hematopoiesis.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)