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GW10801F

Anti-RNASE1 antibody produced in chicken

Name: Anti-RNASE1 antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-RNS1, Anti-Ribonuclease pancreatic

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About This Item

Codice UNSPSC:

12352203

NACRES:

NA.41

Coniugato:

unconjugated

application:

Clone:

polyclonal

Reattività contro le specie:

human

citations:

tecniche:

western blot: suitable

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-10801F

tecniche

western blot: suitable

N° accesso NCBI

NP_002924.1

N° accesso UniProt

P07998

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RNASE1(6035)

Immunogeno

Immunogen Sequence: GI # 4506547, sequence 1-156

Recombinant pancreatic ribonuclease

Applicazioni

Anti-RNASE1 antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

Azioni biochim/fisiol

RNASE1 encodes a protein that is a subset of the ribonuclease A superfamily. It is a pancreatic type of secretory ribonuclease. It acts on the 3′-side of pyrimidine bases and cleaves internal phosphodiester RNA bonds. It is a monomer and preferentially acts on ds-RNA over ss-RNA. Human RNAse I is involved in the digestion of dietary RNA, regulation of vascular homeostasis and inactivation of the HIV. It is also involved in the activation of immature dendritic cells and induction of cytokine production.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number

049K0562

029K2299

029K2281

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Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease.

Md Tabish Rehman et al.

PloS one, 6(3), e17159-e17159 (2011-03-17)

Human pancreatic ribonuclease (HPR), a member of RNase A superfamily, has a high activity on double stranded (ds) RNA. By virtue of this activity HPR appears to be involved in the host-defense against pathogenic viruses. To delineate the mechanism of

Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.

R Jeremy Johnson et al.

Journal of molecular biology, 368(2), 434-449 (2007-03-14)

The ribonuclease inhibitor protein (RI) binds to members of the bovine pancreatic ribonuclease (RNase A) superfamily with an affinity in the femtomolar range. Here, we report on structural and energetic aspects of the interaction between human RI (hRI) and human

The solution structure and dynamics of human pancreatic ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition.

K E Kövér et al.

Journal of molecular biology, 379(5), 953-965 (2008-05-23)

Human pancreatic ribonuclease (RNase 1) is expressed in many tissues; has several important enzymatic and biological activities, including efficient cleavage of single-stranded RNA, double-stranded RNA and double-stranded RNA-DNA hybrids, digestion of dietary RNA, regulation of vascular homeostasis, inactivation of the

Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.

Victoria J Mar et al.

Pigment cell & melanoma research, 27(6), 1117-1125 (2014-07-22)

Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological associations of RAC1(P29S) in a cohort of 814 primary cutaneous melanomas with known BRAF and NRAS mutation status. The RAC1(P29S) mutation

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