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Key Documents

Altri documenti

GS52

Sigma-Aldrich

GST T2-2, Recombinant Human

Sinonimo/i:

glutathione S-transferase theta 2

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.26

Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in E. coli

Saggio

>95% (SDS-PAGE)

Forma fisica

frozen liquid

Attività specifica

12.6 units/mg protein (as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T2-2 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature.)

PM

25 kDa

Concentrazione

1.91 mg/mL

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... GSTT2(2953)

Descrizione generale

Glutathione S-transferase theta 2 (GSTT2) is an enzyme that in humans is encoded by the GSTT2 gene. GSTT2 is mapped to human chromosome 22q11.2.

Azioni biochim/fisiol

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The θ class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations.

Stoccaggio e stabilità

The enzyme should be used by the end-user customer within 1 year of receipt.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.
Tan K L, et al.
Genomics, 25(2), 381-387 (1995)
Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases.
Allocati N, et al.
Oncogenesis, 7(1), 8-8 (2018)
Glutathione S-transferases: an overview in cancer research.
Di Pietro G, et al.
Expert Opinion on Drug Metabolism & Toxicology, 6(2), 153-170 (2010)
Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Sheehan D, et al.
The Biochemical Journal, 360(1), 1-16 (2001)
B Rodríguez-Santiago et al.
Molecular psychiatry, 15(10), 1023-1033 (2009-06-17)
Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have
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