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Merck
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Key Documents

Altri documenti

F8791

Sigma-Aldrich

5-Fluoro-5′-deoxyuridine

Sinonimo/i:

Doxifluridine, 5′dFUrd

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About This Item

Formula empirica (notazione di Hill):
C9H11FN2O5
Numero CAS:
3094-09-5
Peso molecolare:
246.19
Numero CE:
221-440-1
Numero MDL:
MFCD00866530
Codice UNSPSC:
12352200
ID PubChem:
24278444

Livello qualitativo

200

Stringa SMILE

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1
ZWAOHEXOSAUJHY-ZIYNGMLESA-N

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Azioni biochim/fisiol

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Camostat mesylate ≥98% (HPLC)

Sigma-Aldrich

SML0057

Camostat mesylate

Cytosine β-D-arabinofuranoside hydrochloride crystalline

Sigma-Aldrich

C6645

Cytosine β-D-arabinofuranoside hydrochloride

Gemcitabine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

G6423

Gemcitabine hydrochloride

5-bromo-2′-deossiuridina ≥99% (HPLC)

Sigma-Aldrich

B5002

5-bromo-2′-deossiuridina

Hitoshi Miyakoshi et al.
Journal of medicinal chemistry, 55(7), 2960-2969 (2012-03-13)
Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies
Yujia Wen et al.
Pharmacogenetics and genomics, 21(8), 476-488 (2011-06-07)
To determine whether cellular apoptosis is a suitable phenotypic trait for pharmacogenomics studies by evaluating caspase 3/7-mediated activity in lymphoblastoid cell lines after treatment with six chemotherapeutic agents: 5'-deoxyfluorouridine, pemetrexed, cytarabine, paclitaxel, carboplatin, and cisplatin. Using monozygotic twin pair and
Gregory Lucien Bellot et al.
Journal of cancer research and clinical oncology, 138(3), 463-482 (2011-12-22)
Since primary tumor cells from patients have been used as a model for assessment of drug response for individual patients, this study aims to evaluate the reliability of such a model in colorectal cancer (CRC) in predicting the response of
Yasuko Naganuma et al.
Cancer science, 102(8), 1545-1552 (2011-06-03)
Uterine carcinosarcoma is a highly aggressive gynecological neoplasm that responds poorly to conventional chemotherapy and radiotherapy. Metronomic chemotherapy is accepted as a new approach for cancer treatment, and its underlying mechanism seems to involve the suppression of angiogenesis. However, the
G J Peters et al.
International journal of cancer, 54(3), 450-455 (1993-05-28)
Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632)
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