F8648

Monoclonal Anti-Interferon-γ−Carboxyfluorescein antibody produced in mouse

clone 25723.11, purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: Monoclonal Anti-Interferon-γ
• Codice UNSPSC: 51111800
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: carboxyfluorescein conjugate
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 25723.11, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable
• Isotipo: IgG2b
• N° accesso UniProt: P01579
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Informazioni sul gene: human ... IFNG(3458)

Descrizione

Descrizione generale

Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. There are two types of IFNs, type I (IFN-α and IFN-β) and type II (IFN-γ). IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis. The most studied function of IFN-γ is priming the antigen presenting cells by up regulating major histocompatibility (MHC) Class I molecules. IFN-γ has clinical applications in autoimmune diseases (rheumatoid arthritis), multiple sclerosis, cancer, HIV and fungal infections. Anti-Interferon-γ recognizes intracellular human IFN-γ. The product is prepared by conjugation of carboxyfluorescein to Protein G purified IFN-γ monoclonal antibody.

Specificità

The conjugates will identify and quantitate cells containing intracellular forms of human IFN-γ by flow cytometry.

Immunogeno

recombinant human IFN-γ

Applicazioni

Anti-interferon-γ antibody may be used for detection of intracellular IGN-γ in peripheral blood lymphocytes by adding 10 μL of the antibody to 1-5 X 10⁵ cells.

Stato fisico

Solution in phosphate buffered saline containing 0.1% sodium azide.

Nota sulla preparazione

Purified antibody is conjugated to carboxyfluorescein.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)