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Documenti fondamentali

F4429

Sigma-Aldrich

FAUC 213

≥98% (HPLC), solid

Sinonimo/i:

2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine

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About This Item

Formula empirica (notazione di Hill):
C18H19ClN4
Numero CAS:
Peso molecolare:
326.82
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white

Solubilità

DMSO: ~24 mg/mL (with warming up to 60 °C)
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Clc1ccc(cc1)N2CCN(CC2)Cc3cc4ccccn4n3

InChI

1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
DTRXURJDKOYCCD-UHFFFAOYSA-N

Informazioni sul gene

Applicazioni

FAUC 213 has been used as a selective dopamine receptor D4-R antagonist:
  • to test its effect on the expression of luteinizing hormone in eel pituitary primary cell culture
  • to test its effect on bupropion induced hypophagia and locomotion in rats
  • to test its modulatory effects on rat basolateral amygdala in the presence of dopamine

Azioni biochim/fisiol

FAUC 213 displays antipsychotic properties and may be of use in studies related to behavioral neurobiology and neurochemistry.
Highly selective D4 dopamine receptor full antagonist

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

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S Löber et al.
Journal of medicinal chemistry, 44(17), 2691-2694 (2001-08-10)
Structure dependent efficacy studies in the field of selective D4 ligands led to the 2-aminomethyl substituted azaindole 2 (FAUC 213) that displayed strong D4 binding, high subtype selectivity, and complete antagonist properties in ligand-induced mitogenesis experiments. According to our schematic
Frank Boeckler et al.
Psychopharmacology, 175(1), 7-17 (2004-03-10)
2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213) is a highly selective antagonist at the dopamine D(4) receptor subtype. It was designed as a derivative of two partial antagonists and has been proven to be a complete antagonist in mitogenesis assay. In the present study
Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats.
Janhunen, et al.
Obesity (Silver Spring, Md.), 21, E700-E708 (2017)
Hironori Ohshiro et al.
Neuropharmacology, 61(4), 857-866 (2011-06-21)
The amygdala receives dopaminergic innervation, and dopamine (DA) enhances various activities in cognitive and emotional behaviors. Periodic bursts of spontaneous inhibitory postsynaptic currents (IPSCs) with a low (<1 Hz) inter-event frequency have been observed in projection neurons of the basolateral
C Jolly et al.
Journal of neuroendocrinology, 28(9) (2016-07-28)
In various vertebrate species, dopamine (DA) exerts an inhibitory action on reproduction. In the European eel, DA plays a pivotal role in the inhibitory control of gonadotroph function and the blockade of puberty. In vivo studies have suggested that this

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