E9530
Erythropoietin from mouse
recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, suitable for cell culture
Sinonimo/i:
EPO
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About This Item
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Ricombinante
expressed in NSO cells
Saggio
≥90% (SDS-PAGE)
Forma fisica
lyophilized powder
Potenza
1.030 ng/mL
PM
~36 kDa by SDS-PAGE
predicted mol wt 18.6 kDa
Confezionamento
pkg of 10 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Epo(13856)
Descrizione generale
EPO (erythropoietin) gene is localized to human chromosome 7q22. This protein is predominantly produced by the cortex cells of kidney, as well as a variety of tissues including female reproductive organs. It is a glycoprotein, which has a molecular weight of 34kDa. It is produced as a 193-amino acid precursor protein, which is cleaved to produce a secreted protein of 166-amino acid.
Azioni biochim/fisiol
EPO (erythropoietin) plays an essential role in the growth and differentiation of erythrocyte progenitor cells. It is involved in the pathogenesis of myomatous erythrocytosis syndrome, which is characterized by erythrocytosis and myomatous uterus. It acts as a ligand for a homodimer of EPO-receptor (Epo-R), which is localized to the surface of immature erythroid cells. This interaction leads to inhibition of apoptosis and facilitation of cell proliferation and differentiation to mature erythrocytes.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Risultati analitici
The biological acitivity is measured by its ability to stimulate cell proliferation using TF-1 cell line.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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L T Vlasveld et al.
The Netherlands journal of medicine, 66(7), 283-285 (2008-07-30)
Myomatous erythrocytosis syndrome is defined by the combination of erythrocytosis, myomatous uterus and persistent restoration of normal haematological values after hysterectomy. A pathogenic role of erythropoietin is suggested by clinical and experimental data. A postmenopausal patient is described with the
Norio Suzuki
The Tohoku journal of experimental medicine, 235(3), 233-240 (2015-03-20)
Erythrocytes play an essential role in the delivery of oxygen from the lung to every organ; a decrease in erythrocytes (anemia) causes hypoxic stress and tissue damage. To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it
Sheila E Francis
Methods in molecular biology (Clifton, N.J.), 330, 331-340 (2006-07-19)
The development of techniques for the in vitro differentiation of mouse embryonic stem (ES) cells has provided researchers with the tools to investigate vascular development as would occur in an early embryo. Mice lacking the vascular integrins have various defects
Luca Weltert et al.
Transfusion, 55(7), 1644-1654 (2015-02-24)
We conducted a prospective single-blind randomized study to assess whether a single 80,000 IU dose of human recombinant erythropoietin (HRE), given just 2 days before cardiac surgery, could be effective in reducing perioperative allogeneic red blood cell transfusion (aRBCt). Six-hundred
Honghao Zhang et al.
Experimental and therapeutic medicine, 10(5), 1925-1930 (2015-12-08)
Chronic kidney disease (CKD) is commonly accompanied by inflammation and anemia; however, the pathogenesis of CKD is unclear. Expression of resistin, a cysteine-rich secretory plasma protein, is correlated with the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lipoprotein-associated
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