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E8031

Sigma-Aldrich

Esmolol

≥98% (HPLC), solid

Sinonimo/i:

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C16H26NClO4
Numero CAS:
81161-17-3
Peso molecolare:
331.83
Numero MDL:
MFCD00941432
Codice UNSPSC:
12352200
ID PubChem:
329799075
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Punto di fusione

89.0-90.6 °C

Solubilità

H2O: 12 mg/mL

Ideatore

Baxter

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H
GEKNCWBANDDJJL-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB1(153) , ADRB2(154)

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Applicazioni

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Azioni biochim/fisiol

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.
Esmolol hydrochloride is a ultrashort-acting β1 adrenoceptor antagonist (β1 receptor occupancy = 84.7%).

Caratteristiche e vantaggi

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves

Certificati d'analisi (COA)

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Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry
Alarfaj NA and El-Tohamy MF
International Journal of Electrochemical Science (2016)
George Dimopoulos et al.
The Journal of surgical research, 198(1), 175-184 (2015-06-16)
Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa would prolong survival and modulate immune response. Acute pyelonephritis was induced in 80
Yong-Feng Zhu et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A, 25(11), 903-907 (2015-11-18)
To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery. Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were divided into an AD group (lavage with normal saline containing adrenaline [1:500,000], n = 30)

Articoli

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

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