E5286

Enniatin B1

from Gnomonia errabunda, ≥95% (HPLC)

• Sinonimo/i: 2-(N-Methyl-L-isoleucine) Enniatin B, 3-Butan-2-yl-4,10,16-trimethyl-6,9,12,15,18-penta(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
• Formula empirica (notazione di Hill): C₃₄H₅₉N₃O₉
• Numero CAS: 19914-20-6
• Peso molecolare: 653.85
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Origine biologica: Gnomonia errabunda
• Livello qualitativo: 200
• Saggio: ≥95% (HPLC)
• Solubilità: DMSO: 10 mg/mL; ethanol: 10 mg/mL; methanol: 10 mg/mL
• Temperatura di conservazione: −20°C
• InChI: 1S/C34H59N3O9/c1-16-22(12)25-34(43)46-27(20(8)9)30(39)36(14)23(17(2)3)32(41)44-26(19(6)7)29(38)35(13)24(18(4)5)33(42)45-28(21(10)11)31(40)37(25)15/h17-28H,16H2,1-15H3; UQCSETXJXJTMKO-UHFFFAOYSA-N

Descrizione

Applicazioni

Enniatin B1 has been used as a mycotoxin in the cell viability assay of primary porcine brain capillary endothelial cells (PBCEC) and human brain microvascular capillary cells (HBMEC). It has also been used as an analytical standard in mass spectrometry measurements.

Azioni biochim/fisiol

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311 + H331
• Consigli di prudenza: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable