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Key Documents

Altri documenti

E1631

Sigma-Aldrich

β-Estradiol 17-valerate

≥98%

Sinonimo/i:

1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

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About This Item

Formula empirica (notazione di Hill):
C23H32O3
Numero CAS:
979-32-8
Peso molecolare:
356.50
Beilstein:
2480357
Numero CE:
213-559-2
Numero MDL:
MFCD00056541
Codice UNSPSC:
12352200
ID PubChem:
24894423
NACRES:
NA.77

Origine biologica

synthetic

Livello qualitativo

100

Saggio

≥98%

Forma fisica

powder

tecniche

ELISA: suitable

Solubilità

acetone: 25 mg/mL, hazy, colorless

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3
RSEPBGGWRJCQGY-UHFFFAOYSA-N

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Descrizione generale

β-Estradiol 17-valerate is a synthetic estrogen.

Applicazioni

β-Estradiol 17-valerate has been used:
  • in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
  • to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
  • to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Azioni biochim/fisiol

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.

Pittogrammi

Health hazardEnvironment
GHS08,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H351 - H361fd - H362 - H410

Classi di pericolo

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Huib A A M Van Vliet et al.
The Cochrane database of systematic reviews, (11)(11), CD009038-CD009038 (2011-11-11)
Quadriphasic oral contraceptives have been developed to reduce the adverse effects of oral contraceptives and are presented as more physiological since they mimic the natural cycle. However, suggested disadvantages of quadriphasic oral contraceptives include a possible increased risk of pill-taking
Christophe Blockeel et al.
Reproductive biomedicine online, 24(3), 272-280 (2012-02-03)
This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian
Stephen M Junk et al.
Fertility and sterility, 98(4), 888-892 (2012-07-28)
To describe an optimized protocol for oocyte in vitro maturation (IVM) that achieves improved implantation and ongoing pregnancy rates in women with polycystic ovaries (PCO) and polycystic ovary syndrome (PCOS). Prospective cohort study. Hospital fertility unit. Women with PCO and
Emily L Gilbert et al.
Hypertension (Dallas, Tex. : 1979), 63(3), 616-623 (2013-12-25)
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder with a high prevalence of hypertension and cardiovascular disease. Because SLE predominantly affects women, estrogen is commonly implicated as a contributor to SLE disease progression. Using an established mouse model
Kevin Hollevoet et al.
Oncotarget, 9(17), 13623-13636 (2018-03-24)
Antibody gene transfer presents an appealing alternative to conventional antibody protein therapy. This pre-clinical study evaluates the impact of various parameters on the pharmacokinetics and efficacy of in vivo expressed DNA-based anti-HER2 monoclonal antibodies (mAbs), newly engineered and delivered via
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