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D6000

Sigma-Aldrich

2′-Deoxyadenosine 5′-di­phos­phate sodium salt

Sinonimo/i:

dADP

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About This Item

Formula empirica (notazione di Hill):
C10H15N5O9P2 · xNa+
Numero CAS:
72003-83-9
Peso molecolare:
411.20 (free acid basis)
Numero CE:
276-280-5
Numero MDL:
MFCD00083610
Codice UNSPSC:
41106305
ID PubChem:
24893990
NACRES:
NA.51

Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥95% (HPLC)

Stato

powder

Temperatura di conservazione

−20°C

Stringa SMILE

[Na].Nc1ncnc2n(cnc12)C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3

InChI

1S/C10H15N5O9P2.Na.H/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19);;
KZGAPWRJMWSNQO-UHFFFAOYSA-N

Descrizione generale

2′-Deoxyadenosine5′-di­phos­phate (dADP) is a purine containing adenine as the nucleobase. It isproduced as a product of hypoxanthine oxidase action on hypoxanthine duringpurine degradation in the body.

Applicazioni

2′-Deoxyadenosine 5′-diphosphate (dADP) may be used for the synthesis of deoxyadenylate oligonucleotides with enzymes such as polynucleotide phosphorylase from Escherichia coli. dADP is used as an inhibitor of bacterial poly(A) polymerase. DeoxyADP may be use as an alternative substrate or inhibitor for studies of ATPase and DNA and RNA polymerase specificity.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311 + H331,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
SLBR3060V
SLBF5603V
080M5059
108K5059
107K5053

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M P Deutscher
The Journal of biological chemistry, 253(16), 5579-5584 (1978-08-25)
Poly(A) synthesis and degradation have been examined in Escherichia coli cells made permeable to nucleotides by treatment with toluene. Although newly synthesized poly(A) is normally rapidly degraded in this system, extraction of the soluble portion of the cell effectively eliminates
Kevin N Kirouac et al.
Journal of molecular biology, 407(3), 382-390 (2011-02-08)
The ability of DNA polymerases to differentiate between ribonucleotides and deoxribonucleotides is fundamental to the accurate replication and maintenance of an organism's genome. The active sites of Y-family DNA polymerases are highly solvent accessible, yet these enzymes still maintain a
S Gillam et al.
Nucleic acids research, 2(5), 613-624 (1975-05-05)
Polynucleotide phosphorylase from Escherichia coli can be used to catalyse the addition of short tracts of deoxyadenylate residues to the 3'-termini of deoxyribooligonucleotides of the type pdAn-dN (where dN = dC, dT or dG) using dADP as donor. Similarly, the
Mahmoud Kandeel et al.
Journal of bioenergetics and biomembranes, 42(5), 361-369 (2010-08-17)
Nucleoside diphosphate kinases (NDKs) play a key role in maintaining the intracellular energy resources as well as the balance of nucleotide pools. Recently, attention has been directed to NDKs owing to its role in activating various chemotherapeutic agents. The binding

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