D5446
7,8-Dihydroxyflavone hydrate
≥98% (HPLC)
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Formula empirica (notazione di Hill):
C15H10O4 · xH2O
Numero CAS:
Peso molecolare:
254.24 (anhydrous basis)
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Condizioni di stoccaggio
desiccated
Solubilità
DMSO: 24 mg/mL
Temperatura di conservazione
room temp
Stringa SMILE
Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
InChI
1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
COCYGNDCWFKTMF-UHFFFAOYSA-N
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Applicazioni
7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).
Azioni biochim/fisiol
7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.
7,8-Dihydroxyflavone is a selective TrkB receptor agonist
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem
Jang M, et al.
eLife, 8, e42156-e42156 (2019)
7, 8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction
Chen C, et al.
Rejuvenation Research, 17(3), 249-254 (2014)
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang MS, et al.
The Journal of Experimental Medicine, 214(10), 2947-2966 (2017)
Vasorelaxing and antihypertensive effects of 7, 8-dihydroxyflavone
Huai R
American Journal of Hypertension, 27(5), 750-760 (2013)
Maria N Schultz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 346-354 (2020-08-21)
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene Ube3a The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.