D3072

Doxycycline Hydrochloride, Ready Made Solution

100 mg/mL in DMSO, ≥95.0% (HPLC)

• Sinonimo/i: α-6-Deoxy-5-hydroxytetracycline hydrochloride, 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-, Doxylin, Idocyklin, Vibramycin hyclate, Vibramycin hydrochloride
• Formula empirica (notazione di Hill): C₂₂H₂₄N₂O₈ · HCl
• Numero CAS: 10592-13-9
• Peso molecolare: 480.90
• Numero MDL: MFCD03427564
• Codice UNSPSC: 51284028
• NACRES: NA.85

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Sterilità: 0.22 μm filtered
• Saggio: ≥95.0% (HPLC)
• Stato: liquid
• Concentrazione: 100 mg/mL in DMSO
• Solubilità: DMSO: 100 mg/mL
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria; mycoplasma; parasites
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: −20°C
• InChI: 1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1; VLUQVUWDECWBTL-UQVCFKGQSA-N

Descrizione

Descrizione generale

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Applicazioni

<ul>
<li><strong>AAPS PharmSciTech: </strong>Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024).</li>
<li><strong>European Journal of Pharmacology: </strong>Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024).</li>
</ul>

Altre note

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 188.6 °F - closed cup
• Punto d’infiammabilità (°C): 87 °C - closed cup