C9992

Anti-Caveolin-2

~1 mg/mL, affinity isolated antibody, buffered aqueous solution, suitable for western blot: 1 μg/mL

• Numero MDL: MFCD01633098
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen ~20 kDa
• Reattività contro le specie: pig (predicted), mouse, rat, canine, human (predicted)
• Concentrazione: ~1 mg/mL
• tecniche: indirect immunofluorescence: suitable; western blot: 1-2 μg/mL using whole extract of mouse 3T3-L1 adipocytes or rat kidney NRK cells
• N° accesso UniProt: P51636
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CAV2(858) ; mouse ... Cav2(12390) ; rat ... Cav2(363425)

Descrizione

Descrizione generale

Caveolin-2 is an isoform of caveolin, an integral transmembrane protein of the caveolae membranes. It has a molar mass of 20-22 kDa and is a major coat protein found in caveolae of most cell types. It exists as two isoforms α and β due to alternative splicing of the respective mRNAs. Caveolin-2α corresponds to the full-length protein (20 kDa, 162 amino acids), whereas caveolin-2β isoform lacks a 13 amino acid sequence at its N-terminus.

Immunogeno

synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse caveolin-2, conjugated to KLH. This sequece is identical in rat caveolin-2, highly conserved (90% identity) in human, dog, and pig caveolin-2, and is not found in caveolin-1 and caveolin-3.

Azioni biochim/fisiol

Caveolin-2 colocalizes and forms a hetero-oligomeric complex with caveolin-1 in vivo. Caveolins family members function as scaffolding proteins to organize and concentrate specific lipids such as cholesterol and glycosylphosphatidylinositol (GPI) and lipid modified signaling molecules within caveolae membranes. Caveolin-2 is phosphorylated on Ser²³ and Ser³⁶ and modulates caveolin-1-dependent caveola formation.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)