C9012

Bis(cyclohexanone)oxaldihydrazone

≥95% purity (TLC), powder

• Sinonimo/i: Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
• Formula empirica (notazione di Hill): C₁₄H₂₂N₄O₂
• Numero CAS: 370-81-0
• Peso molecolare: 278.35
• Beilstein: 2388004
• Numero CE: 206-729-2
• Numero MDL: MFCD00001659
• Codice UNSPSC: 12171500
• ID PubChem: 24893128
• NACRES: NA.47

Proprietà

• Nome del prodotto: Bis(cyclohexanone)oxaldihydrazone, ≥95% (TLC)
• Saggio: ≥95% (TLC)
• Stato: powder
• tecniche: titration: suitable
• Colore: white/clear to off-white
• Punto di fusione: 210-214 °C (lit.)
• Solubilità: acetic acid: 50 mg/mL, colorless to very faintly brown
• applicazioni: diagnostic assay manufacturing; hematology; histology
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
• InChI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20); DSRJIHMZAQEUJV-UHFFFAOYSA-N

Descrizione

Applicazioni

• Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
• It has been used to induce demyelination in mice.
• It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.

Azioni biochim/fisiol

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)