C8895

Clofazimine

≥98% (TLC), powder, antileprosy drug

• Sinonimo/i: N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
• Formula empirica (notazione di Hill): C₂₇H₂₂Cl₂N₄
• Numero CAS: 2030-63-9
• Peso molecolare: 473.40
• Numero CE: 217-980-2
• Numero MDL: MFCD00056793
• Codice UNSPSC: 12352200
• ID PubChem: 24893114
• NACRES: NA.77

Proprietà

• Nome del prodotto: Clofazimine,
• Stato: powder
• Livello qualitativo: 200
• Spettro attività antibiotica: mycobacteria
• Modalità d’azione: protein synthesis | interferes
• Ideatore: Novartis
• Stringa SMILE: CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
• InChI: 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+; WDQPAMHFFCXSNU-BGABXYSRSA-N

Descrizione

Descrizione generale

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Applicazioni

Clofazimine has been used:

• for antimicrobial preparation
• to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
• to model drug-induced hepatic granulomatous inflammation
• to study the in vivo cargo storage capacity of macrophages

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Stoccaggio e stabilità

This product is stored at room temperature.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves