C4483
CD152/Fc Chimera, Cytolytic from mouse
recombinant, expressed in NS.1 cells, buffered aqueous solution
Sinonimo/i:
CTLA4/Fc Chimera, cytolytic
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About This Item
Origine biologica
mouse
Livello qualitativo
Ricombinante
expressed in NS.1 cells
Saggio
≥99% (SDS-PAGE)
Stato
buffered aqueous solution
PM
97 kDa
Confezionamento
pkg of 1 mg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
Impurezze
≤1 EU/mg protein Endotoxin level (LAL test)
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Cd152(12477) , Ctla4(12477)
Descrizione generale
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Azioni biochim/fisiol
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
Altre note
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
Stato fisico
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
Nota sulla preparazione
Purified from serum-free tissue culture supernatant
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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